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Brain MRI and Electrophysiologic Abnormalities in Preclinical and Clinical Adrenomyeloneuropathy Neurol 42:85-91, Aubourg,P.,et al, 1992 See this aricle in Pubmed Article Abstract We describe the neurophysiologic abnormalities in 17 patients with clinical adrenomyeloneuropathy(AMN),an adult phenotype of X-linked adrenoleukodystrophy(ALD).These abnormalities also allowed the early recognition of the AMN phenotype in three asymptomatic boys with biochemically proven ALD.In 14/16 adult AMN patients,there were cerebral white matter abnormalities on MRI which were severe and comparable with cerebral ALD in four of the patients.

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